Cocaine.

As well as beng a drug that can turn even the most mild mannered fool into a loud opinionated jaw clenching sweating pontificating twat, it can also make previously posh pieces of totty look like an ex bare knuckle queen called Gloria.
"Years of cocaine abuse appears to have finally caught up with Tara Palmer-Tomkinson, after shocking photographs revealed her once perfect nose to be on the brink of collapse.

Appearing at the Grazia Lifetime Achievement awards Saturday night, guests were horrified to see a large dent on the bridge of her nose.

One guest said: "Tara was dressed up and looked terrific, but her nose was in a terrible state. I couldn't stop staring at it because it had such a strange indentation. It was the talk of the party."

Friends of the I'm A Celebrity star, who has been clean for more than six years, now fear her former £400-a-day drug habit may have left her scarred for life."
That and I spent the best part of an hour on Saturday listening to some chap tell me all about his relationship with his sort of estranged dad, his sort of estranged brother and his -by proxy- sort of estranged nieces and nephews, all while he gurned and clenched and sweated his pointy head off. OOOOOhhh yes. Worra lorra fun.